N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression.

N-acetylcysteine attenuates hexavalent chromium-induced hypersensitivity through inhibition of cell death, ROS-related signaling and cytokine expression.

Chromium hypersensitivity (chromium-induced allergic contact dermatitis) is an important issue in occupational skin disease. Hexavalent chromium (Cr (VI)) can activate the Akt, Nuclear factor κB (NF-κB), and Mitogen-activated protein kinase (MAPK) pathways and induce cell death, via the effects of r...

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Bibliographic Details
Main Authors: Yu-Hsuan Lee, Shih-Bin Su, Chien-Cheng Huang, Hamm-Ming Sheu, Jui-Chen Tsai, Chia-Ho Lin, Ying-Jan Wang, Bour-Jr Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4172727?pdf=render

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http://europepmc.org/articles/PMC4172727?pdf=render

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