Extracellular Vesicle Biomarkers Reveal Inhibition of Neuroinflammation by Infliximab in Association with Antidepressant Response in Adults with Bipolar Depression

Extracellular Vesicle Biomarkers Reveal Inhibition of Neuroinflammation by Infliximab in Association with Antidepressant Response in Adults with Bipolar Depression

Accumulating evidence suggests that neuroinflammation is involved in bipolar disorder (BD) pathogenesis. The tumor necrosis factor-alpha (TNF-α) antagonist infliximab was recently reported to improve depressive symptoms in a subpopulation of individuals with BD and history of childhood maltreatment....

Full description

Bibliographic Details
Main Authors: Rodrigo B. Mansur, Francheska Delgado-Peraza, Mehala Subramaniapillai, Yena Lee, Michelle Iacobucci, Nelson Rodrigues, Joshua D. Rosenblat, Elisa Brietzke, Victoria E. Cosgrove, Nicole E. Kramer, Trisha Suppes, Charles L. Raison, Sahil Chawla, Carlos Nogueras-Ortiz, Roger S. McIntyre, Dimitrios Kapogiannis
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
bipolar disorder
inflammation
cytokines
childhood trauma
depression
Online Access:https://www.mdpi.com/2073-4409/9/4/895

Internet

https://www.mdpi.com/2073-4409/9/4/895

Similar Items