Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism

Abstract The dopamine (DA) system has a profound impact on reward-motivated behavior and is critically involved in neurodevelopmental disorders, such as autism spectrum disorder (ASD). Although DA defects are found in autistic patients, it is not well defined how the DA pathways are altered in ASD a...

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Bibliographic Details
Main Authors: Owen Y. Chao, Salil S. Pathak, Hao Zhang, Nathan Dunaway, Jay-Shake Li, Claudia Mattern, Susanne Nikolaus, Joseph P. Huston, Yi-Mei Yang
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Brain
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13041-020-00649-7