Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum

Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum

The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention and early degradation. It is known that CFTR exit from the ER is mediated by sp...

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Bibliographic Details
Main Authors: João D. Santos, Sara Canato, Ana S. Carvalho, Hugo M. Botelho, Kerman Aloria, Margarida D. Amaral, Rune Matthiesen, Andre O. Falcao, Carlos M. Farinha
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
CFTR
endoplasmic reticulum quality control
arginine-framed tripeptides
diacidic code
interactome
folding
trafficking
Online Access:https://www.mdpi.com/2073-4409/8/4/353

Internet

https://www.mdpi.com/2073-4409/8/4/353

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