Octreotide-Targeted Lcn2 siRNA PEGylated Liposomes as a Treatment for Metastatic Breast Cancer

Octreotide-Targeted Lcn2 siRNA PEGylated Liposomes as a Treatment for Metastatic Breast Cancer

Lcn2 overexpression in metastatic breast cancer (MBC) can lead to cancer progression by inducing the epithelial-to-mesenchymal transition and enhancing tumor angiogenesis. In this study, we engineered a PEGylated liposomal system encapsulating lipocalin 2 (Lcn2) small interfering RNA (Lcn2 siRNA) fo...

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Bibliographic Details
Main Authors: Vrinda Gote, Dhananjay Pal
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Bioengineering
Subjects:
triple-negative breast cancer (TNBC)
gene therapy
peptide ligand targeting
vascular endothelial growth factor (VEGF)
epithelial-to-mesenchymal transition (EMT)
tumor angiogenesis
Online Access:https://www.mdpi.com/2306-5354/8/4/44

Internet

https://www.mdpi.com/2306-5354/8/4/44

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