Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition.

Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition.

Genetic polymorphisms of the organic cation transporter 2 (OCT2), encoded by SLC22A2, have been investigated in association with metformin disposition. A functional decrease in transport function has been shown to be associated with the OCT2 variants. Using metabolomics, our study aims at a comprehe...

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Bibliographic Details
Main Authors: Im-Sook Song, Do Yup Lee, Min-Hye Shin, Hyunmi Kim, Yun Gyong Ahn, Inmyoung Park, Kyoung Heon Kim, Tobias Kind, Jae-Gook Shin, Oliver Fiehn, Kwang-Hyeon Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3348126?pdf=render

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http://europepmc.org/articles/PMC3348126?pdf=render

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