Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

We report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides (ASOs) modified with α-L-locked nucleic acid (LNA) and related modifications targeting phosphatase and tensin homologue (PTEN) messenger RNA in mice. α-L-LNA represents the α-anomer of e...

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Bibliographic Details
Main Authors: Punit P Seth, Ali Jazayeri, Jeff Yu, Charles R Allerson, Balkrishen Bhat, Eric E Swayze
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
gapmer
hepatotoxicity
immune stimulation
oligonucleotides
α-L-LNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301007

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http://www.sciencedirect.com/science/article/pii/S2162253116301007

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