Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma

Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma

Abstract Background Chemoresistance of glioblastoma (GBM) is a feature of this devastating disease. This study is to determine the relationship between Hedgehog (HH)/Gli1 signaling pathway and chemoresistance to temozolomide (TMZ) in human GBM. Methods We analyzed Gli1 nuclear staining and O6-methyl...

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Bibliographic Details
Main Authors: Ke Wang, Dongjiang Chen, Zhouqi Qian, Daming Cui, Liang Gao, Meiqing Lou
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Cancer Cell International
Subjects:
Glioblastoma
Chemoresistance
MGMT
Temozolomide
Hedgehog signaling pathway
Gli1
Online Access:http://link.springer.com/article/10.1186/s12935-017-0491-x

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http://link.springer.com/article/10.1186/s12935-017-0491-x

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