Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells

Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal of mammalian cells. With site-specific integrat...

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Bibliographic Details
Main Authors: Agustin Vega-Crespo, Brian Truong, Kip J Hermann, Jason P Awe, Katherine M Chang, Patrick C Lee, Benjamen E Schoenberg, Lily Wu, James A Byrne, Gerald S Lipshutz
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300220