In Vivo and In Vitro Analyses of Novel Peptidomimetic Disruptors for the Serotonin 5-HT2C Receptor Interaction With Phosphatase and Tensin Homolog

In Vivo and In Vitro Analyses of Novel Peptidomimetic Disruptors for the Serotonin 5-HT2C Receptor Interaction With Phosphatase and Tensin Homolog

Hypofunction of the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) has been implicated in a variety of disorders including substance use disorders. As such, approaches to enhance 5-HT2CR signaling display therapeutic potential. In the present study, we show that disruption of the 5-HT2CR interaction wit...

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Bibliographic Details
Main Authors: Claudia A. Soto, Huang-Chi Du, Robert G. Fox, Taegyun Yang, James Hooson, Noelle C. Anastasio, Scott R. Gilbertson, Kathryn A. Cunningham
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
serotonin 5-HT2C receptor
protein–protein interactions
protein phosphatase and tensin homolog
peptidomimetics
drug discrimination
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00907/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00907/full

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