Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation

Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation

Abstract Mouse peritoneal macrophages consist of two subsets: large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs), defined as CD11bhiF4/80hi and CD11b+F4/80lo cells, respectively. We reveal that SPMs, but not LPMs, have the ability to present antigens to naïve CD4+ T cells. C...

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Bibliographic Details
Main Authors: Eri Takenaka, Anh Van Vo, Yumi Yamashita-Kanemaru, Akira Shibuya, Kazuko Shibuya
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Peritoneal Macrophages
Alum Adjuvant
Mediastinal Lymph Nodes
Trinitrophenyl (TNP)
MHC class-II (MHCII)
Online Access:https://doi.org/10.1038/s41598-018-33437-4

Internet

https://doi.org/10.1038/s41598-018-33437-4

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