Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice.

Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice.

We investigated the relationship between gut health, visceral fat dysfunction and metabolic disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet (HFD). Circulating glucose, insulin and inflammatory markers were measured. Proximal colon barrier function was ass...

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Bibliographic Details
Main Authors: Yan Y Lam, Connie W Y Ha, Craig R Campbell, Andrew J Mitchell, Anuwat Dinudom, Jan Oscarsson, David I Cook, Nicholas H Hunt, Ian D Caterson, Andrew J Holmes, Len H Storlien
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3311621?pdf=render

Internet

http://europepmc.org/articles/PMC3311621?pdf=render

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