The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder

The translocator protein (18 kDa) (TSPO) recently attracted increasing attention in the pathogenesis of post-traumatic stress disorder (PTSD). This study is testing the hypothesis that the overexpression of TSPO in hippocampus dentate gyrus (DG) could alleviate the anxiogenic-like response in the mi...

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Bibliographic Details
Main Authors: Xiao-Ying Zhang, Wang Wei, You-Zhi Zhang, Qiang Fu, Wei-Dong Mi, Li-Ming Zhang, Yun-Feng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
TSPO
post-traumatic stress disorder
neurosteroid
neurogenesis
hippocampus
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01364/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01364/full

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