NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons

NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons

Abstract Background NRXN1 deletions are identified as one of major rare risk factors for autism spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co-morbidity with epilepsy, and the latter is associated with excessive neuronal firing. NRXN1 encodes hundreds of presynaptic n...

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Bibliographic Details
Main Authors: Sahar Avazzadeh, Leo R. Quinlan, Jamie Reilly, Katya McDonagh, Amirhossein Jalali, Yanqin Wang, Veronica McInerney, Janusz Krawczyk, Yicheng Ding, Jacqueline Fitzgerald, Matthew O’Sullivan, Eva B. Forman, Sally A. Lynch, Sean Ennis, Niamh Feerick, Richard Reilly, Weidong Li, Xu Shen, Guangming Yang, Yin Lu, Hilde Peeters, Peter Dockery, Timothy O’Brien, Sanbing Shen, Louise Gallagher
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Neuroscience
Subjects:
ASD
Excitability
Induced pluripotent stem cell
Neurexin
RNA sequencing
Online Access:https://doi.org/10.1186/s12868-021-00661-0

Internet

https://doi.org/10.1186/s12868-021-00661-0

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