Advanced Glycation End Products Induce Vascular Smooth Muscle Cell-Derived Foam Cell Formation and Transdifferentiate to a Macrophage-Like State

Background. Advanced glycation end products play an important role in diabetic atherosclerosis. The effects of advanced glycation end products (AGEs) on vascular smooth muscle cell- (VSMC-) derived foam cell formation and phenotypic transformation are unknown. Methods. Serological and histological s...

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Bibliographic Details
Main Authors: Zhengyang Bao, Lihua Li, Yue Geng, Jinchuan Yan, Zhiyin Dai, Chen Shao, Zhen Sun, Lele Jing, Qiwen Pang, Lili Zhang, Xiaodong Wang, Zhongqun Wang
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2020/6850187