Apoptin Gene Delivery by the Functionalized Polyamidoamine (PAMAM) Dendrimer Modified with Ornithine Induces Cell Death of HepG2 Cells

Apoptin Gene Delivery by the Functionalized Polyamidoamine (PAMAM) Dendrimer Modified with Ornithine Induces Cell Death of HepG2 Cells

The use of tumor-specific therapeutic agents is a promising option for efficient and safe nonviral gene transfer in gene therapy. In this study, we describe the efficacy of polyamidoamine (PAMAM)-based nonviral gene delivery carriers, namely, an ornithine conjugated PAMAM (PAMAM-O) dendrimer in deli...

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Bibliographic Details
Main Authors: Yoonhee Bae, Su Jeong Song, Ji Young Mun, Kyung Soo Ko, Jin Han, Joon Sig Choi
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:Polymers
Subjects:
apoptin
nonviral gene delivery
apoptosis
polyamidoamine dendrimer
gene therapy
Online Access:http://www.mdpi.com/2073-4360/9/6/197

Internet

http://www.mdpi.com/2073-4360/9/6/197

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