Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate.

The mechanism of rapid energy supply to the brain, especially to accommodate the heightened metabolic activity of excited states, is not well-understood. We explored the role of glycogen as a fuel source for neuromodulation using the noradrenergic stimulation of glia in a computational model of the...

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Bibliographic Details
Main Authors: Jay S Coggan, Daniel Keller, Corrado Calì, Heikki Lehväslaiho, Henry Markram, Felix Schürmann, Pierre J Magistretti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC6160207?pdf=render