T Cell Receptor Alpha Chain Genes in the Teleost Ballan Wrasse (Labrus bergylta) Are Subjected to Somatic Hypermutation

T Cell Receptor Alpha Chain Genes in the Teleost Ballan Wrasse (Labrus bergylta) Are Subjected to Somatic Hypermutation

Previously, somatic hypermutation (SHM) was considered to be exclusively associated with affinity maturation of antibodies, although it also occurred in T cells under certain conditions. More recently, it has been shown that SHM generates diversity in the variable domain of T cell receptor (TCR) in...

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Bibliographic Details
Main Authors: Sumaira Bilal, Kai Kristoffer Lie, Øystein Sæle, Ivar Hordvik
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
T cell receptor
ballan wrasse
TCRα
polymorphism
somatic hypermutation
activation-induced cytidine deaminase motif
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01101/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01101/full

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