Competitive evolution of NSCLC tumor clones and the drug resistance mechanism of first-generation EGFR-TKIs in Chinese NSCLC patients

Competitive evolution of NSCLC tumor clones and the drug resistance mechanism of first-generation EGFR-TKIs in Chinese NSCLC patients

Purpose: Although many studies have reported on the resistance mechanism of first-generation EGFR TKIs (1st EGFR TKIs) treatment, large-scale dynamic ctDNA mutation analysis based on liquid biopsy for non-small cell lung cancer (NSCLC) in the Chinese population is rare. Using in-depth integration an...

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Bibliographic Details
Main Authors: Qinfang Deng, Boxiong Xie, Leilei Wu, Xianxiu Ji, Chao Li, Li Feng, Qiyu Fang, Yuchen Bao, Jialu Li, Shengnan Jin, Chunming Ding, Yixue Li, Songwen Zhou
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Heliyon
Subjects:
Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018325143

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http://www.sciencedirect.com/science/article/pii/S2405844018325143

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