Polysaccharide Chain Length of Lipopolysaccharides From Salmonella Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity in vivo

Polysaccharide Chain Length of Lipopolysaccharides From Salmonella Minnesota Is a Determinant of Aggregate Stability, Plasma Residence Time and Proinflammatory Propensity in vivo

Lipopolysaccharides (LPS) originate from the outer membrane of Gram-negative bacteria and trigger an inflammatory response via the innate immune system. LPS consist of a lipid A moiety directly responsible for the stimulation of the proinflammatory cascade and a polysaccharide chain of variable leng...

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Bibliographic Details
Main Authors: Wahib Sali, Danish Patoli, Jean-Paul Pais de Barros, Jérôme Labbé, Valérie Deckert, Vincent Duhéron, Naig Le Guern, Denis Blache, Denis Chaumont, Eric Lesniewska, Benoit Gasquet, Catherine Paul, Mathieu Moreau, Franck Denat, David Masson, Laurent Lagrost, Thomas Gautier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Microbiology
Subjects:
aggregation
inflammation
lipopolysaccharides
mouse
pharmacokinetics
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01774/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01774/full

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