The Outer Pore and Selectivity Filter of TRPA1.

TRPA1 (transient-receptor-potential-related ion channel with ankyrin domains) is a direct receptor or indirect effector for a wide variety of nociceptive signals, and thus is a compelling target for development of analgesic pharmaceuticals such as channel blockers. Recently, the structure of TRPA1 w...

Full description

Bibliographic Details
Main Authors: Adam P Christensen, Nurunisa Akyuz, David P Corey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5100928?pdf=render