Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis

Abstract Alzheimer’s disease (AD) is the most common form of dementia in the elderly. According to the amyloid hypothesis, the accumulation and deposition of amyloid-beta (Aβ) peptides play a key role in AD. Soluble Aβ (sAβ) oligomers were shown to be involved in pathological hypersynchronisation of...

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Bibliographic Details
Main Authors: Inès R. H. Ben-Nejma, Aneta J. Keliris, Jasmijn Daans, Peter Ponsaerts, Marleen Verhoye, Annemie Van der Linden, Georgios A. Keliris
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Resting-state fMRI
Neuronal networks
Aβ
Tet-off APP mice
Online Access:http://link.springer.com/article/10.1186/s40478-019-0810-7

Internet

http://link.springer.com/article/10.1186/s40478-019-0810-7

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