Extended release promethazine HCl using acrylic polymers by freeze-drying and spray-drying techniques: formulation considerations

Extended release promethazine HCl using acrylic polymers by freeze-drying and spray-drying techniques: formulation considerations

The present study investigated a novel extended release system of promethazine hydrochloride (PHC) with acrylic polymers Eudragit RL100 and Eudragit S100 in different weight ratios (1:1 and 1: 5), and in combination (0.5+1.5), using freeze-drying and spray-drying techniques. Solid dispersions were c...

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Bibliographic Details
Main Authors: Ruchi Tiwari, Birendra Srivastava, Gaurav Tiwari, Awanik Rai
Format: Article
Language:English
Published: Universidade de São Paulo 2009-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Cloridrato de prometazina
Fármacos
Eudragit RL100
Eudragit S100
Polímeros acrílicos
Secagem por aspersão
Liofilização
Formulações farmacêuticas
Promethazine hydrochloride
Drugs
Acrylic polymers
Spray drying
Freeze drying
Extended realease
Pharmaceutical formulations
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400029

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400029

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