Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouse

Disruption of zinc transporter ZnT3 transcriptional activity and synaptic vesicular zinc in the brain of Huntington’s disease transgenic mouse

Abstract Background Huntington’s disease (HD) is a neurodegenerative disease that involves a complex combination of psychiatric, cognitive and motor impairments. Synaptic dysfunction has been implicated in HD pathogenesis. However, the mechanisms have not been clearly delineated. Synaptic vesicular...

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Bibliographic Details
Main Authors: Li Niu, Li Li, Shiming Yang, Weixi Wang, Cuifang Ye, He Li
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell & Bioscience
Subjects:
Synaptic vesicular zinc
Zinc transporter 3
Sp1
Transcriptional inhibition
Synaptic dysfunction
Huntingtin
Online Access:http://link.springer.com/article/10.1186/s13578-020-00459-3

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http://link.springer.com/article/10.1186/s13578-020-00459-3

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