Inflammasome Inhibition Suppresses Alveolar Cell Permeability Through Retention of Neuregulin-1 (NRG-1)

Inflammasome Inhibition Suppresses Alveolar Cell Permeability Through Retention of Neuregulin-1 (NRG-1)

Background: Neuregulin (NRG)-1-human epidermal receptor (HER)-2 signaling pathway is a key regulator of IL-1β-mediated pulmonary inflammation and epithelial permeability. The inflammasome is a newly discovered molecular platform required for caspase-1 activation and maturation of IL-1β. However, the...

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Bibliographic Details
Main Authors: Rajanbabu Venugopal, Lakshmi Galam, Ruan Cox, Jutaro Fukumoto, Young Cho, Prasanna Tamarapu Parthasarathy, Richard F. Lockey, Narasaiah Kolliputi
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Alveolar cell permeability
Reactive oxygen species
Acute lung injury
IL-1β
Macrophage
Inflammasome
Online Access:http://www.karger.com/Article/FullText/430169

Internet

http://www.karger.com/Article/FullText/430169

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