AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M

AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M

Abstract Aquaglyceroporins (AQPs) allow the movement of glycerol that is required for triglyceride formation in hepatic stellate cells (HSC), as key cellular source of fibrogenesis in the liver. The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associat...

Full description

Bibliographic Details
Main Authors: Matteo Tardelli, Francesca V. Bruschi, Thierry Claudel, Veronica Moreno-Viedma, Emina Halilbasic, Fabio Marra, Merima Herac, Thomas M. Stulnig, Michael Trauner
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-14557-9

Internet

https://doi.org/10.1038/s41598-017-14557-9

Similar Items