Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study.

Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study.

Genome-wide association studies (GWASs) assess correlation between traits and DNA sequence variation using large numbers of genetic variants such as single nucleotide polymorphisms (SNPs) distributed across the genome. A GWAS produces many trait-SNP associations with low p-values, but few are replic...

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Bibliographic Details
Main Authors: Albert O Edwards, Brooke L Fridley, Katherine M James, Anil K Sharma, Julie M Cunningham, Nirubol Tosakulwong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2583911?pdf=render

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http://europepmc.org/articles/PMC2583911?pdf=render

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