Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C

Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C

BACKGROUND: Steatosis is common in hepatitis C virus (HCV)-infected patients and likely accelerates fibrosis progression. Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. The objective of the...

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Main Authors: Robert P Myers, Djamila Messous, Thierry Poynard, Francoise Imbert-Bismut
Format: Article
Language:English
Published: Hindawi Limited 2007-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2007/876076
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spelling doaj-8b61c8ea63474cb3be0c78b157e646a82020-11-24T23:52:34ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79002007-01-0121528929410.1155/2007/876076Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis CRobert P Myers0Djamila Messous1Thierry Poynard2Francoise Imbert-Bismut3Liver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaService d’Hépato-Gastro-Entérologie, Hôpital La Pitié-Salpêtrière, Paris, FranceService d’Hépato-Gastro-Entérologie, Hôpital La Pitié-Salpêtrière, Paris, FranceService de Biochimie, Hôpital La Pitié-Salpêtrière, Paris, FranceBACKGROUND: Steatosis is common in hepatitis C virus (HCV)-infected patients and likely accelerates fibrosis progression. Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. The objective of the present study was to determine the clinical and histological correlates of serum leptin in HCV-infected patients, and to determine its utility in predicting liver histological lesions.http://dx.doi.org/10.1155/2007/876076
collection DOAJ
language English
format Article
sources DOAJ
author Robert P Myers
Djamila Messous
Thierry Poynard
Francoise Imbert-Bismut
spellingShingle Robert P Myers
Djamila Messous
Thierry Poynard
Francoise Imbert-Bismut
Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C
Canadian Journal of Gastroenterology
author_facet Robert P Myers
Djamila Messous
Thierry Poynard
Francoise Imbert-Bismut
author_sort Robert P Myers
title Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C
title_short Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C
title_full Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C
title_fullStr Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C
title_full_unstemmed Association between Leptin, Metabolic Factors and Liver Histology in Patients with Chronic Hepatitis C
title_sort association between leptin, metabolic factors and liver histology in patients with chronic hepatitis c
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 2007-01-01
description BACKGROUND: Steatosis is common in hepatitis C virus (HCV)-infected patients and likely accelerates fibrosis progression. Leptin, the peptide product of the obesity gene (ob), has been implicated in hepatic fibrogenesis; circulating levels of leptin correlate with body fat mass. The objective of the present study was to determine the clinical and histological correlates of serum leptin in HCV-infected patients, and to determine its utility in predicting liver histological lesions.
url http://dx.doi.org/10.1155/2007/876076
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