Pyrazolo[3,4-<i>d</i>]pyrimidine Tyrosine Kinase Inhibitors Induce Oxidative Stress in Patient-Derived Glioblastoma Cells

Pyrazolo[3,4-<i>d</i>]pyrimidine Tyrosine Kinase Inhibitors Induce Oxidative Stress in Patient-Derived Glioblastoma Cells

Background: Glioblastoma (GBM) highly expresses Src tyrosine kinase involved in survival, proliferation, angiogenesis and invasiveness of tumor cells. Src activation also reduces reactive oxygen species (ROS) generation, whereas Src inhibitors are able to increase cellular ROS levels. Methods: Pro-o...

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Bibliographic Details
Main Authors: Ana Kostić, Sofija Jovanović Stojanov, Ana Podolski-Renić, Marija Nešović, Miodrag Dragoj, Igor Nikolić, Goran Tasić, Silvia Schenone, Milica Pešić, Jelena Dinić
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Brain Sciences
Subjects:
glioblastoma
Src tyrosine kinase inhibitor
oxidative stress
anticancer activity
Online Access:https://www.mdpi.com/2076-3425/11/7/884

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https://www.mdpi.com/2076-3425/11/7/884

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