ChIP-seq defined genome-wide map of TGFβ/SMAD4 targets: implications with clinical outcome of ovarian cancer.

ChIP-seq defined genome-wide map of TGFβ/SMAD4 targets: implications with clinical outcome of ovarian cancer.

Deregulation of the transforming growth factor-β (TGFβ) signaling pathway in epithelial ovarian cancer has been reported, but the precise mechanism underlying disrupted TGFβ signaling in the disease remains unclear. We performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) to inve...

Full description

Bibliographic Details
Main Authors: Brian A Kennedy, Daniel E Deatherage, Fei Gu, Binhua Tang, Michael W Y Chan, Kenneth P Nephew, Tim H-M Huang, Victor X Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3143154?pdf=render

Internet

http://europepmc.org/articles/PMC3143154?pdf=render

Similar Items