Integrated analysis of promoter mutation, methylation and expression of AKT1 gene in Chinese breast cancer patients.

Integrated analysis of promoter mutation, methylation and expression of AKT1 gene in Chinese breast cancer patients.

BACKGROUND:As downstream mediators of PI3K /PTEN /AKT /mTORC1 pathway, the AKT isoforms play critical roles in tumorgenesis. Although the pleiotropic effects of AKT1 in breast cancer have been reported, the genetic and epigenetic characteristics of AKT1 promoter region in breast cancer remains to be...

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Bibliographic Details
Main Authors: Jianfu Heng, Xinwu Guo, Wenhan Wu, Yue Wang, Guoli Li, Ming Chen, Limin Peng, Shouman Wang, Lizhong Dai, Lili Tang, Jun Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5354459?pdf=render

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http://europepmc.org/articles/PMC5354459?pdf=render

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