Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response.

Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response.

Prior studies suggest that the impaired healing seen in diabetic wounds derives from a state of persistent hyper-inflammation characterized by harmful increases in inflammatory leukocytes including macrophages. However, such studies have focused on wounds at later time points (day 10 or older), and...

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Bibliographic Details
Main Authors: Stephen Wood, Vijayakumar Jayaraman, Erica J Huelsmann, Brian Bonish, Derick Burgad, Gayathri Sivaramakrishnan, Shanshan Qin, Luisa A DiPietro, Andrew Zloza, Chunxiang Zhang, Sasha H Shafikhani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3950222?pdf=render

Internet

http://europepmc.org/articles/PMC3950222?pdf=render

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