Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis

BackgroundAging is one of the key contributing factors for chronic obstructive pulmonary diseases (COPD) and other chronic inflammatory lung diseases. Here, we determined how aging contributes to the altered gene expression related to mitochondrial function, cellular senescence, and telomeric length...

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Bibliographic Details
Main Authors: Krishna P. Maremanda, Isaac K. Sundar, Dongmei Li, Irfan Rahman
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
mitochondria
cellular senescence
telomere
DNA damage
aging
smokers
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.584637/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.584637/full

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