Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma

Aberrant excitatory rewiring of layer V pyramidal neurons early after neocortical trauma

Lesioned neuronal circuits form new functional connections after a traumatic brain injury (TBI). In humans and animal models, aberrant excitatory connections that form after TBI may contribute to the pathogenesis of post-traumatic epilepsy. Partial neocortical isolation (“undercut” or “UC”) leads to...

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Bibliographic Details
Main Authors: D. Koji Takahashi, Feng Gu, Isabel Parada, Shri Vyas, David A. Prince
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Neurobiology of Disease
Subjects:
Neocortex
Traumatic brain injury
Excitatory synapses
Excitatory circuits
EPSCs
Laser scanning photostimulation
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611630047X

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http://www.sciencedirect.com/science/article/pii/S096999611630047X

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