Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling

Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling

Acute kidney injury (AKI) is a significant medical problem worldwide. Ischemia-reperfusion (I/R) injury of the kidney is a major cause of AKI. However, the pathogenesis that contributes to renal I/R injury is still unclear. Apoptosis repressor with caspase recruitment domain (ARC) is abundantly expr...

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Bibliographic Details
Main Authors: Ke Yingjie, Yan Haihong, Chen Lingwei, Zhong Sen, Dai Yuanting, Cai Shasha, Pan Liutong, Wang Ying, Zhou Min
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Acute kidney injury (AKI)
ARC
Inflammation
Mitochondrial injury and apoptosis
AKT/mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218387638

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http://www.sciencedirect.com/science/article/pii/S0753332218387638

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