Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

BackgroundFerroptosis is a recently identified iron-dependent form of cell death as a result of increased reactive oxygen species (ROS) and lipid peroxidation. In this study, we investigated whether ferroptosis aggravated diabetic nephropathy (DN) and damaged renal tubules through hypoxia-inducible...

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Bibliographic Details
Main Authors: Xiaomeng Feng, Shuo Wang, Zhencheng Sun, Hengbei Dong, Haitian Yu, Mengxiu Huang, Xia Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Endocrinology
Subjects:
ferroptosis
diabetic nephropathy
renal tubular injury
heme oxygenase-1
hypoxia-inducible factor-1α
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.626390/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.626390/full

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