The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia

The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia

Abstract Background The nudix family member enzyme MutT homologue-1 (MTH1) hydrolyses the oxidized nucleotides 8-oxo-dGTP and 2-hydroxy-dATP and thus prevents the incorporation of damaged nucleotides into nuclear and mitochondrial DNA. Therefore MTH1 was proposed to protect cancer cells from oxidati...

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Bibliographic Details
Main Authors: Mosche Pompsch, Julia Vogel, Fabian Classen, Philip Kranz, George Iliakis, Helena Riffkin, Ulf Brockmeier, Eric Metzen
Format: Article
Language:English
Published: BMC 2018-11-01
Series:BMC Cancer
Subjects:
8-oxo-Guanosin
DNA damage repair
MutT homologue-1
Oxygen
Online Access:http://link.springer.com/article/10.1186/s12885-018-5095-x

Internet

http://link.springer.com/article/10.1186/s12885-018-5095-x

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