Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons

Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons

Background: The chromosome 22q11.2 deletion is an extremely high risk genetic factor for various neuropsychiatric disorders; however, the 22q11.2 deletion-related brain pathology in humans at the cellular and molecular levels remains unclear. Methods: We generated iPS cells from healthy controls (co...

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Bibliographic Details
Main Authors: Yuko Arioka, Emiko Shishido, Itaru Kushima, Toshiaki Suzuki, Ryo Saito, Atsu Aiba, Daisuke Mori, Norio Ozaki
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:EBioMedicine
Subjects:
22q11.2 deletion
Neuropsychiatric disorders
iPS cells
Dopaminergic neurons
PERK
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420305144

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http://www.sciencedirect.com/science/article/pii/S2352396420305144

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