Ethoxysanguinarine, a Novel Direct Activator of AMP-Activated Protein Kinase, Induces Autophagy and Exhibits Therapeutic Potential in Breast Cancer Cells

Ethoxysanguinarine, a Novel Direct Activator of AMP-Activated Protein Kinase, Induces Autophagy and Exhibits Therapeutic Potential in Breast Cancer Cells

Ethoxysanguinarine (Eth) is a benzophenanthridine alkaloid extracted from Macleaya cordata (Willd) R. Br. It possesses antibacterial and antiviral activities and offers therapeutic benefits for the treatment of respiratory syndrome virus-induced cytopathic effects. However, the effect of Eth on huma...

Full description

Bibliographic Details
Main Authors: Yuan Si, Jiu Wang, Xuewen Liu, Tong Zhou, Yuchen Xiang, Te Zhang, Xianhui Wang, Tingting Feng, Li Xu, Qingqing Yu, Huzi Zhao, Ying Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
ethoxysanguinarine
breast cancer
autophagy
AMP-activated protein kinase
molecular docking
pharmacokinetic
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01503/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01503/full

Similar Items