Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol

Synthesis of Some New Fluorinated Hexahydroquinoline and Acridinedione Derivatives in Trifluoroethanol

This article describes one-pot synthesis of new fluorinated hexahydroquinoline derivatives via unsymmetric Hantzsch reaction involving 5-trifluoromethyl-1,3-cyclohexanedione, aldehydes, acetoacetate ester, and ammonium acetate in trifluoroethanol (TFE). The reaction is simple and rapid with high yie...

Full description

Bibliographic Details
Main Authors:	Cosmas O. Okoro, Mumiye A. Ogunwale, Tasneem Siddiquee
Format:	Article
Language:	English
Published:	MDPI AG 2012-04-01
Series:	Applied Sciences
Subjects:	unsymmetric Hantzsch reaction dihydropyridine trifluoromethyl hexahydroquinoline acridinedione trifluoroethanol
Online Access:	http://www.mdpi.com/2076-3417/2/2/368

Similar Items

Synthesis and Laccase-Mediated Oxidation of New Condensed 1,4-Dihydropyridine Derivatives
by: Jelena Milovanovic, et al.
Published: (2021-06-01)

Microwave-promoted three-component Hantzsch synthesis of acridinediones under green conditions
by: Behzad Zeynizadeh, et al.
Published: (2019-10-01)

Crystal structures of 1-(4-chlorophenyl)-4-(4-methylphenyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid and 4-(4-methoxyphenyl)-1-(4-methylphenyl)-2,5-dioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile
by: Omyma A. Abd Allah, et al.
Published: (2021-04-01)

Direct Enantiomeric Resolution of Seventeen Racemic 1,4-Dihydropyridine-Based Hexahydroquinoline Derivatives by HPLC
by: Jiayi Sun, et al.
Published: (2019-05-01)

Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
by: Ke-Hua Zhang, et al.
Published: (2012-05-01)

Minimum inhibitory concentration of ciprofloxacin in combination with hexahydroquinoline derivatives against Staphylococcus aureus
by: Yousefi M, et al.
Published: (2012-12-01)

Sulfonated-Titanomagnetite Nanoparticles as Potential and Recyclable Catalyst for the Synthesis of Dihydroquinazoline and Hexahydroquinoline Derivatives under Solvent-Free Condition
by: Davood Azarifar, et al.
Published: (2021-04-01)

Sol-gel preparation of fluorine-containing hydrophobic SiO2 coating by using trifluoroethanol as dispersant and modifier simultaneously
by: Longqiang Ye, et al.
Published: (2020-03-01)

Oxidation of Hantzsch 1,4- Dihydropyridines to Pyridines with Thallium Triacetate
by: Mohammad Mahmoodi Hashemi, et al.
Published: (2003-12-01)

Synthesis and Aromatization of Hantzsch 1,4-Dihydropyridines under Microwave Irradiation. An Overview
by: Annie Mayence, et al.
Published: (2003-04-01)

2-Amino-4-(4-methoxyphenyl)-1-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile
by: Asmaa H. A. Tamam, et al.
Published: (2018-02-01)

Synthesis and crystal structures of a bis(3-hydroxy-cyclohex-2-en-1-one) and two hexahydroquinoline derivatives
by: Scott A. Steiger, et al.
Published: (2020-02-01)

Crystal structure of ethyl 4-[4-(dimethylamino)phenyl]-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
by: Scott A. Steiger, et al.
Published: (2018-10-01)

Sulfated Zirconia-Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) Under Solventless Conditions: Competitive Multicomponent Biginelli vs. Hantzsch Reactions
by: Guillermo NegrÃƒÂ³n-Silva, et al.
Published: (2006-10-01)

An Efficient Method for The Synthesis of Dihydropyridine by Hantzsch Reaction with Fe/SiO2 Nano Heterogeneous Catalysts
by: Ateeq Rahman, et al.
Published: (2020-12-01)

Trifluoroethanol Modulates Amyloid Formation by the All α-Helical URN1 FF Domain
by: Patrizia Marinelli, et al.
Published: (2013-08-01)

Regioselective synthesis and antioxidant activity of a novel class of mono and C2-symmetric bis-1,2,3-triazole and acridinedione grafted macromolecules
by: Rajesh Raju, et al.
Published: (2020-12-01)

The Effect of Trifluoroethanol and Glycerol on the Thermal Properties of Collagen Using Optical Displacement-Enhanced Heterodyne Polarimeter
by: Chien-Ming Wu, et al.
Published: (2015-11-01)

Effect of trifluoroethanol on antibody reactivity against corresponding and nonrelated antigens
by: S. A. Bobrovnik, et al.
Published: (2018-07-01)

4-(3,5-Dibromo-4-hydroxyphenyl)-3-butoxycarbonyl-5-ethoxycarbonyl-2-methyl-6-phenyl-1,4-dihydropyridine
by: Zhen Wang, et al.
Published: (2011-04-01)

Sodium Hypochlorite-Dowex 1X8-200: A Convenient Oxidizing Reagant
by: Mahammad Mahmoodi Hashemi, et al.
Published: (2002-12-01)

One pot four component sequential synthesis of hexahydroquinoline derivatives in aqueous media via enaminone intermediates: A green protocol
by: D. Patil, et al.
Published: (2017-01-01)

Bismuth nitrate as an efficient recyclable catalyst for the one-pot multi component synthesis of 1,4-dihydropyridine derivatives through unsymmetrical Hantzsch reaction
by: S. Sheik Mansoor, et al.
Published: (2016-09-01)

An efficient one-pot multi component synthesis of polyhydroquinoline derivatives through Hantzsch reaction catalysed by Gadolinium triflate
by: S. Sheik Mansoor, et al.
Published: (2017-02-01)

Crystal structure of (S)-1-(1,3-benzothiazol-2-yl)-2,2,2-trifluoroethanol
by: Svitlana V. Shishkina, et al.
Published: (2014-09-01)

Evaluation of Expression of NorA Efflux Pump in Ciprofloxacin Resistant Staphylococcus Aureus Against Hexahydroquinoline Derivative by Real-Time PCR
by: Mohammad Reza Pourmand, et al.
Published: (2014-06-01)

MCM-BP as a Novel Nanomagnetic Reusable Basic Catalyst for the one Pot Solvent-Free Synthesis of Dihydropyridine, Polyhydroquinoline and Polyhydroacridine Derivatives via Hantzsch Multicomponent Condensation Reaction
by: Manoochehr Aghajeri, et al.
Published: (2020-06-01)

Anti-Toxoplasma gondii activity of 5-oxo-hexahydroquinoline derivatives: synthesis, in vitro and in vivo evaluations, and molecular docking analysis
by: Mohammadsaeid Zahedi, et al.
Published: (2020-01-01)

Correction: One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity
by: Giovanna Bosica, et al.
Published: (2021-08-01)

One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity
by: Giovanna Bosica, et al.
Published: (2020-11-01)

Peroxynitric Acid: A Convenient Oxygen Source for Oxidation of Organic Compounds Catalyzed by Polyimide-Supported Manganese (III) Tetrakis(4-methoxylphenyl)porphyrin Acetate
by: Gholamreza Karimipour, et al.
Published: (2017-05-01)

An efficient Hantzsch synthesis of 1,4-dihydropyridines using p-toluenesulfonic acid under solvent-free condition
by: Masoud Nasr-Esfahani, et al.
Published: (2014-03-01)

Protein Environment: A Crucial Triggering Factor in Josephin Domain Aggregation: The Role of 2,2,2-Trifluoroethanol
by: Cristina Visentin, et al.
Published: (2018-07-01)

Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis
by: Magnus Rueping, et al.
Published: (2012-02-01)

Use of pyridinium ionic liquids as catalysts for the synthesis of 3,5-bis(dodecyloxycarbonyl)-1,4-dihydropyridine derivative
by: Pajuste Karlis, et al.
Published: (2011-02-01)

Crystal structure of 2-amino-4-(4-chlorophenyl)-1-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile
by: Shaaban K. Mohamed, et al.
Published: (2015-12-01)

Crystal structure, Hirshfeld surface and frontier molecular orbital analysis of 10-benzyl-9-(3-ethoxy-4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione
by: N. Suresh Babu, et al.
Published: (2020-04-01)

Crystal structure of 10-benzyl-9-(3,4-dimethoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione
by: N. Sureshbabu, et al.
Published: (2015-09-01)

One-pot synthesis of polyhydropyridine derivatives via Hantzsch four component condensation in water medium: Use of a recyclable Lewis acid [Ce(SO<sub>4</sub>)<sub>2</sub>.4H<sub>2</sub>O] catalyst
by: Elaheh Mosaddegh, et al.
Published: (2012-12-01)

Structure-reactivity correlation for the kinetics of the reaction of substituted 4-phenyl-1,4-dihydropyridines formation
by: Urošević Jovica V., et al.
Published: (2013-01-01)