Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice

Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice

Abstract Background Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a high cumulative dose of DOX, the mechanisms of its l...

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Bibliographic Details
Main Authors: Takaaki Furihata, Satoshi Maekawa, Shingo Takada, Naoya Kakutani, Hideo Nambu, Ryosuke Shirakawa, Takashi Yokota, Shintaro Kinugawa
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Anticancer agent
LV dysfunction
Cardiac toxicity
Thiazolidinediones
Online Access:https://doi.org/10.1186/s40360-021-00495-w

Internet

https://doi.org/10.1186/s40360-021-00495-w

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