A novel model of ischemia in rats with middle cerebral artery occlusion using a microcatheter and zirconia ball under fluoroscopy

Abstract The failure of neuroprotective treatment-related clinical trials may be partially caused by unestablished animal models. Existing animal models are less likely to provide occlusion confined to the middle cerebral artery (MCA), making transarterial intervention difficult. We aimed to develop...

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Bibliographic Details
Main Authors: Teppei Komatsu, Hiroki Ohta, Haruhiko Motegi, Junichi Hata, Koshiro Terawaki, Makoto Koizumi, Kanako Muta, Hirotaka James Okano, Yasuyuki Iguchi
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92321-w