Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain. Using mouse models of paralog deficiency, we demonstrate that they are not eq...

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Bibliographic Details
Main Authors: Alejandro Villarino, Arian Laurence, Gertraud W Robinson, Michael Bonelli, Barbara Dema, Behdad Afzali, Han-Yu Shih, Hong-Wei Sun, Stephen R Brooks, Lothar Hennighausen, Yuka Kanno, John J O'Shea
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
T cells
autoimmunity
STAT5
cytokine
STAT signaling
transcription factors
Online Access:https://elifesciences.org/articles/08384

Internet

https://elifesciences.org/articles/08384

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