Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition

Hypothermia is potently neuroprotective, but the molecular basis of this effect remains obscure. Changes in neuronal tau protein are of interest, since tau becomes hyperphosphorylated in injury-resistant, hypothermic brains. Noting inter-species differences in tau isoforms, we have used functional c...

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Bibliographic Details
Main Authors: Nina M. Rzechorzek, Peter Connick, Matthew R. Livesey, Shyamanga Borooah, Rickie Patani, Karen Burr, David Story, David J.A. Wyllie, Giles E. Hardingham, Siddharthan Chandran
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:EBioMedicine
Subjects:
Hypothermia
Preconditioning
Neuroprotection
Tau protein
Protein phosphatase 2A (PP2A)
Hyperphosphorylation
Human cortical neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415302437

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http://www.sciencedirect.com/science/article/pii/S2352396415302437

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