Attenuation and Stability of CHIKV-NoLS, a Live-Attenuated Chikungunya Virus Vaccine Candidate

Attenuation and Stability of CHIKV-NoLS, a Live-Attenuated Chikungunya Virus Vaccine Candidate

Our previous investigation of the nucleolar localisation sequence (NoLS) of chikungunya virus (CHIKV) capsid protein demonstrated the role of capsid in CHIKV virulence. Mutating the NoLS of capsid in CHIKV led to the development of a unique live-attenuated CHIKV vaccine candidate, termed CHIKV-NoLS....

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Bibliographic Details
Main Authors: Eranga Abeyratne, Joseph R. Freitas, Ali Zaid, Suresh Mahalingam, Adam Taylor
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Vaccines
Subjects:
alphavirus
chikungunya virus
live-attenuated
vaccine
preclinical
Online Access:http://www.mdpi.com/2076-393X/7/1/2

Internet

http://www.mdpi.com/2076-393X/7/1/2

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