A magnesium-induced triplex pre-organizes the SAM-II riboswitch.

A magnesium-induced triplex pre-organizes the SAM-II riboswitch.

Our 13C- and 1H-chemical exchange saturation transfer (CEST) experiments previously revealed a dynamic exchange between partially closed and open conformations of the SAM-II riboswitch in the absence of ligand. Here, all-atom structure-based molecular simulations, with the electrostatic effects of M...

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Bibliographic Details
Main Authors: Susmita Roy, Heiko Lammert, Ryan L Hayes, Bin Chen, Regan LeBlanc, T Kwaku Dayie, José N Onuchic, Karissa Y Sanbonmatsu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5352136?pdf=render

Internet

http://europepmc.org/articles/PMC5352136?pdf=render

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