Inhibitory effects of the JAK inhibitor CP690,550 on human CD4<sup>+ </sup>T lymphocyte cytokine production

Inhibitory effects of the JAK inhibitor CP690,550 on human CD4<sup>+ </sup>T lymphocyte cytokine production

<p>Abstract</p> <p>Background</p> <p>The new JAK3 inhibitor, CP690,550, has shown efficacy in the treatment of rheumatoid arthritis. The present study was undertaken to assess the effects of CP690,550 on cytokine production and cellular signaling in human CD4<sup>...

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Bibliographic Details
Main Authors: Yamasaki Satoshi, Aiba Yoshihiro, Jiuchi Yuka, Maeda Yumi, Komori Atsumasa, Koga Tomohiro, Izumi Yasumori, Miyashita Taiichiro, Migita Kiyoshi, Kawakami Atsushi, Nakamura Minoru, Ishibashi Hiromi
Format: Article
Language:English
Published: BMC 2011-08-01
Series:BMC Immunology
Subjects:
CP690
550
cytokines
Janus kinase
signal transducers and activators of transcription
T lymphocytes
Online Access:http://www.biomedcentral.com/1471-2172/12/51

Internet

http://www.biomedcentral.com/1471-2172/12/51

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