The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions

The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions

TFF1 is a protective peptide of the Trefoil Factor Family (TFF), which is co-secreted with the mucin MUC5AC, gastrokine 2 (GKN2), and IgG Fc binding protein (FCGBP) from gastric surface mucous cells. <i>Tff1</i>-deficient mice obligatorily develop antropyloric adenoma and about 30% progr...

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Bibliographic Details
Main Authors: Jörn Heuer, Franziska Heuer, René Stürmer, Sönke Harder, Hartmut Schlüter, Nayara Braga Emidio, Markus Muttenthaler, Dörthe Jechorek, Frank Meyer, Werner Hoffmann
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
gastric cancer
reactive oxygen species
inflammation
trefoil factor, TFF1
FCGBP
gastrokine
Online Access:https://www.mdpi.com/1422-0067/21/7/2508

Internet

https://www.mdpi.com/1422-0067/21/7/2508

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