Not All Next Generation Sequencing Diagnostics are Created Equal: Understanding the Nuances of Solid Tumor Assay Design for Somatic Mutation Detection

Not All Next Generation Sequencing Diagnostics are Created Equal: Understanding the Nuances of Solid Tumor Assay Design for Somatic Mutation Detection

The molecular characterization of tumors using next generation sequencing (NGS) is an emerging diagnostic tool that is quickly becoming an integral part of clinical decision making. Cancer genomic profiling involves significant challenges including DNA quality and quantity, tumor heterogeneity, and...

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Bibliographic Details
Main Authors: Phillip N. Gray, Charles L.M. Dunlop, Aaron M. Elliott
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Cancers
Subjects:
next generation sequencing
cancer panels
target enrichment
copy number
molecular inversion probes
somatic
germline
Online Access:http://www.mdpi.com/2072-6694/7/3/0837

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http://www.mdpi.com/2072-6694/7/3/0837

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