PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA

PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA

The synergic action of the cytostatic drug cyclophosphamide (CP) and fragmented exogenous DNA causes illness and death in mice (Dolgova et al., 2011–2013). The observed «delayed death» effect was most clearly pronounced when the DNA preparation was administered 18 to 30 hours after CP treatment. Thi...

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Bibliographic Details
Main Authors: E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov
Format: Article
Language:English
Published: Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2014-12-01
Series:Vavilovskij Žurnal Genetiki i Selekcii
Subjects:
cyclophosphamide
exogenous dna
bone marrow cells
apoptosis
systemic inflammation
accidental involution of lymphoid organs
Online Access:https://vavilov.elpub.ru/jour/article/view/120

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https://vavilov.elpub.ru/jour/article/view/120

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